The US has charged Venezuela's President Nicolás Maduro and other senior officials in the country with drug trafficking crimes.
The move, which will increase tensions between the two nations, was announced by Attorney General William Barr.
The US also offered a $15 million reward for any information leading to Mr. Maduro's arrest.
It has long accused him of leading a corrupt and brutal regime, a charge he has repeatedly rejected.
Washington backs opposition leader Juan Guaidó, who last year declared himself interim president.